Crimmor the city is laid out in a haphazard manner, much like an actual medieval city. There's no modern grid pattern, its mostly just a jumble of streets that go every which way and are rarely straight. I still get lost, and I built the place!
To ease things I've color coded the extensive set of map points visible on the minimap.
Red: marks safehouses, the guildhall, and the players house, these are
friendly locations where resting is allowed (no resting on the streets
or in some random merchants store!). Red also marks active quest
locations, so your minimap will highlight where you need to go for
quests. The red quest markers are only active while the quest for that
location is open. For locations that have multiple notes, such as a
store that becomes involved in a quest, the quest note takes precedence
so there are not two notes at the same point. (I'm not recoloring a
single note, I use multiple notes and display/hide as appropriate.
Green: these notes indicate a location name, Wight Alley, The Drae, Firesteep Square, Carn Market, etc. These are both for flavor as well as a potential marker to guide players on quests involving locating things ("He hangs out at Carn Market in Purse Ward").
Default color: generic points of interest such as stores.
Blue (may change, the shade I picked looks close to the green) : Dead drops, which function as quest givers. These are only located in the wards of the city you work as a fixer for.
Yellow (may change, looks close to default ingame): area transitions between the sections of the city.